One of the things that people comment on when they work with me is how much of a keyboard shortcut person I am. In fact I really like the fact that Vista supports my typing-preferences and doesn't make me mouse so much. But when I'm presenting, I try to use the mouse as much as I can and stay away from keyboard shortcuts. I just find such presentations hard to follow myself, when I don't know what the demo-ing person is typing and what shortcuts they are using. It's easier to see what they are clicking on.
This became a bit relevant during Speaker Idol when I mused aloud about whether to dock Mark Miller for using CodeRush while demo-ing. Anyone else I would definitely have told not to, but perhaps Mark has a dispensation. I just find that many attendees can't follow along with the blazing speed that CodeRush enables and really lose track of the demo.
Roy Osherove has put together a little utility that displays your shortcuts as you type them. His first post on the topic suggests its value to presenters, while his second one focuses on using it to become more keyboard oriented or to train a coworker to be more keyboard oriented. If you really can't switch to the mouse while presenting, consider using this utility so that people can see what you're doing.