Dan Griffin is working on some samples for client development and blogging his progress as he writes them. His SPOS sample combines workflow with access to local hardware (in this case, a fingerprint reader) to create an application where you could approve, say, purchase orders with a fingerprint swipe. It's a good example of the kind of application that is better as a local client application than something web-based and browser hosted.
He's created a Codeplex site where interim releases are appearing, and a blog category where you can follow his progress, read his musings on what fingerprint reader to buy, and so on. This is a sample designed for you to use in your own work, so follow along and see if it can help you.