I suppose using Source Safe is better than using no source control at all. But it's slow, it can't handle non-text files usefully, it totally doesn't work over a slow network, and it corrupts its database from time to time for no discernible reason. It can't handle multiple people having a file checked out at once, so that forgetting to check in a common file (especially a project or config file) can either completely keep others from working or can make people get in the habit of working outside of source control for long stretches of time. It has had its day and you should replace it.
But let's say you're an all-Microsoft shop and you don't really have the time and energy to go looking for products from other vendors. You like knowing all your stuff works together and you're not entirely sure how you would integrate some other product into Visual Studio and into your workflow. You know someone who works somewhere that doesn't integrate their source control into Visual Studio and it causes them a lot of trouble. You looked at Visual Studio Team System and Team Foundation Server briefly, but at first glance all you saw was Big! Complicated! Expensive! We Don't Need All That! and you've never looked again. Or you talked to a guy who paid someone thousands of dollars to install and it took weeks. You can't afford that and don't like installation nightmare stories.
Sound like you? Sounds like lots of folks I know, and some I mentor. Well I have good news. Word about Visual Studio 2010 is starting to come out and I am liking what I see so far. Take this article by Brian Harry, TFS 2010 for SourceSafe Users. He says that there will be a version of TFS in the 2010 product line that will be as cost effective as Source Safe, can be installed on a domain controller (for folks who really only have one server kicking around) or on your laptop (Vista or Windows 7) and can be installed in a simple Next, Next experience that can take as little as 20 minutes. Wow! He includes the screenshots of the install experience to show you how simple it is.
And you don't just get source control when you do this. You get work item tracking and integration, build automation, all integrated into Visual Studio. If you're using a Team SKU of VS, you're good to go, or if you're using a Pro SKU you just need a TFS CAL and to install Team Explorer and you're good to go. Integrated work item tracking and source control with automatic notifications on checkins and work item changes saves most developers an hour a day. Add that to what you lose swearing at Source Safe and you just HAVE to give this a try.